Tixocortol-21-pivalate home ICD10: L23.9


Formule CAS
C26H38O5S 55560-96-8



Background
Topical corticosteroid used in nasal sprays for the treatment of rhinitis.

Synonyms
(11b)-21-[(2,2-dimethyl-1-oxo-propyl)thi o]-11,17-dihydroxypregn-4-ene-3,20-dione
JO 1016
Pivalone
Procolon
Rectovalone
Tivalon-NT
Tiprederm
Tixocortol-21-pivalate
Tixocortol pivalate

Uses
Nasal sprays

Cross-Reactions
According the A-D grouping, patch-test reactions occur 6-7 times more frequently within well-defined groups of structurally related chemicals than between corticosteroids of different groups (Coopman et al). Tixocortol is used as marker for contact allergy to group A (hydrocortisone) type of steroids.

Unusual Reactions
Airborne contact dermatitis

Back to list of contact allergens


Referenties
1. Boujnah-Khouadja, A., et al., Allergy to 2 new corticoid molecules. Contact Dermatitis, 1984. 11(2): p. 83-7.
2. Camarasa, J.G., et al., Contact allergy to tixocortol pivalate. Contact Dermatitis, 1988. 19(2): p. 147-8.
3. Hausen, B.M. and J. Foussereau, The sensitizing capacity of tixocortol pivalate. Contact Dermatitis, 1988. 18(1): p. 63-4.
4. Coopman, S., H. Degreef, and A. Dooms-Goossens, Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. British Journal of Dermatology, 1989. 121(1): p. 27-34.
5. Dooms-Goossens, A., et al., A survey of the results of patch tests with tixocortol pivalate. Contact Dermatitis, 1989. 20(2): p. 158.
6. Dooms-Goossens, A.E., et al., Contact allergy to corticosteroids: a frequently missed diagnosis?. Journal of the American Academy of Dermatology, 1989. 21(3 Pt 1): p. 538-43.
7. Bircher, A.J., Short induction phase of contact allergy to tixocortol pivalate in a nasal spray. Contact Dermatitis, 1990. 22(4): p. 237-8.
8. Wilkinson, M., P. Cartwright, and J.S. English, The significance of tixocortol-pivalate-positive patch tests in leg ulcer patients. Contact Dermatitis, 1990. 23(2): p. 120-1
9. Lauerma, A.I., Screening for corticosteroid contact sensitivity. Comparison of tixocortol pivalate, hydrocortisone-17-butyrate and hydrocortisone. Contact Dermatitis, 1991. 24(2): p. 123-30.
10. Wilkinson, S.M. and J.S. English, Hydrocortisone sensitivity: a prospective study of the value of tixocortol pivalate and hydrocortisone acetate as patch test markers. Contact Dermatitis, 1991. 25(2): p. 132-3.
11. Wilkinson, S.M. and J.S. English, Hydrocortisone sensitivity. An investigation into the nature of the allergen. Contact Dermatitis, 1991. 25(3): p. 178-81.
12. Burden, A.D. and M.H. Beck, Contact hypersensitivity to topical corticosteroids. British Journal of Dermatology, 1992. 127(5): p. 497-500.
13. Callens, A., et al., Contact stomatitis from tixocortol pivalate. Contact Dermatitis, 1993. 29(3): p. 161.
14. Lauerma, A.I., et al., Contact hypersensitivity to hydrocortisone-free-alcohol in patients with allergic patch test reactions to tixocortol pivalate. Contact Dermatitis, 1993. 28(1): p. 10-4.
15. Lepoittevin, J.P., J. Drieghe, and A. Dooms-Goossens, Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids [see comments]. Archives of Dermatology, 1995. 131(1): p. 31-7.
16. Morton, C. and M. Dohil, A survey of patch test results with tixocortol pivalate in Vancouver. American Journal of Contact Dermatitis, 1995. 6(1): p. 17-18.


Author(s):
Allergology: background information on allergens.

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