.gif "Quaternium 15 (Dowicil 200)")
Background
Quaternium-15 is a broad-spectrum preservative found in many cosmetics and personal care products. Quaternium-15 is one of the formaldehyde-releasing preservatives that include imidazolidinyl urea, diazolidinyl urea, 2-bromo-2-nitropropane-l,3-diol, DMDM (dimethylolmethyl)hydantoin, and tris (hydroxymethyl) nitromethane. Although quaternium-l 5 does release small amounts of formaldehyde, not all patients who are allergic to quaternium-15 are allergic to formaldehyde and vice versa.
SynonymsAzoniaadamantane chloride
Chloroallyl methanamine chloride
Cis-l-(3-chloroallyl)3,5,7-triaza-l-azoniaadamantane chloride
Dowicil 75, 100, 200 (chemically similar)
Dowicil 200
1-(3-Choroallyl)-3,5,7-triaza-1-azoniaadamantane chloride
Methanamine-3-chloroallylochloride
N-(3-chloroallyl) hexaminium chloride
Preventol D1
Quaternium 15
UsesAdhesives
Construction materials
Cosmetics (creams, lotions, shampoos, soaps, etc.)
Inks
Jointing cements
Latex paints
Metal working fluids
Over-the-counter topical medicaments
Paper or paperboard
Polishes
Cross-ReactionsFormaldehyde
Unusual ReactionsBack to list of contact allergens
Referenties
| 1. |
Ford, G.P. and M.H. Beck, Reactions to
Quaternium 15, Bronopol and Germall 115 in a standard series.
Contact Dermatitis, 1986. 14(5): p. 271-4. |
| 2. |
Tosti, A., B.M. Piraccini, and F.
Bardazzi, Occupational contact dermatitis due to quaternium 15.
Contact Dermatitis, 1990. 23(1): p. 41-2. |
| 3. |
Marren, P., et al., Occupational contact
dermatitis due to quaternium 15 presenting as nail dystrophy.
Contact Dermatitis, 1991. 25(4): p. 253-5. |
| 4. |
Perrenoud, D., et al., Frequency of
sensitization to 13 common preservatives in Switzerland. Swiss
Contact Dermatitis Research Group. Contact Dermatitis, 1994. 30(5):
p. 276-9. |
Author(s):
dr. Jan R. Mekkes. Dermatologist, Amsterdam UMC.
ICD10:
L23.9