Primin home ICD10: L23.9

Primin
Formule CAS
C12H16O3  



Background
Primin is the allergen in the plant Primula obconica. In smaller amounts it can also occur in other sorts of primroses. With the falling leaves of the plant or the tiny hairs from underneath the leaves the allergen can easily mingle with the house dust. Primin-caused eczema is often located on hands and face (whirling up dust!). New primin-free cultivars of Primula obconica contain Miconidin and Miconidin methyl ether. These substances are converted to Primin in the skin. Therefore, primin-sensitive persons may also develop a contact allergy to primin-free cultivars of Primula obconica. Primin was also found in the black sea urchin Paracentrotus lividus. Cross reactions are possible with chinoid-type compounds of similar structure that occur in tropical woods such as "Santos-palisander" and teak.

Synonyms
2-Methoxy-6-n-pentyl-4-benzoquinone
2-Methoxy-6-pentylbenzoquinone

Uses
Primula obconica
Plants

Cross-Reactions
Tropical woods such as "Santos-palisander" and teak

Unusual Reactions
Airborne contact dermatitis
Erythema multiforme-like eruption

Back to list of contact allergens


Referenties
1. Fregert, S. and N. Hjorth, The primula allergen primin. Contact Dermatitis, 1977. 3(3): p. 172-4.
2. Schubert, H.J., E. Prater, and M. Sell, Patch testing with primin in white petrolatum. Contact Dermatitis, 1985. 13(4): p. 286.
3. Hausen, B.M., H. Faasch, and W.A. Konig, Primin as the source of sea-urchin hypersensitivity?. Contact Dermatitis, 1987. 17(5): p. 319-21.
4. Ingber, A. and T. Menne, Primin standard patch testing: 5 years experience. Contact Dermatitis, 1990. 23(1): p. 15-9.
5. Shehade, S.A., M.H. Beck, and V.F. Hillier, Epidemiological survey of standard series patch test results and observations on day 2 and day 4 readings. Contact Dermatitis, 1991. 24(2): p. 119-22.
6. Virgili, A. and M. Corazza, Unusual primin dermatitis. Contact Dermatitis, 1991. 24(1): p. 63-4.
7. Tabar, A.I., et al., Primula dermatitis: versatility in its clinical presentation and the advantages of patch tests with synthetic primin. Contact Dermatitis, 1994. 30(1): p. 47-8.
8. Lovell, C.R., Plants and the Skin. 1993, London: Blackwell Scientific Publications.


Author(s):
dr. Jan R. Mekkes. Dermatologist, Amsterdam UMC.

31-12-2015 (JRM) - www.skin-diseases.eu Terug naar homepagina