Methyl-4-hydroxybenzoate home ICD10: L23.9

Methyl-4-hydroxybenzoate

Formula CAS
C8H8O3 99-76-3



Background
Methyl-4-hydroxybenzoate (methyl paraben) along with the other esters of p-hydroxybenzoate (parabens) are the most widely used preservatives in food, drugs, and cosmetics.

Synonyms
4-Hydroxybenzoic acid methyl ester
Methyl-4-hydroxybenzoate
Methyl-p-hydroxybenzoate
Methyl Chemosept
Methyl Parasept
Methylparaben
Nipagin M
Tegosept M

Uses
Beverages
Cosmetics
Creams and lotions
Food (salad dressings, mayonnaise, spiced sauces, mustard, frozen dairy products, baked products)
Pharmaceuticals

Cross-Reactions
Parabens
Hydroquinone monobenzylether
Para group of compounds

Unusual Reactions
Immunologic contact urticaria
Nonimmunologic contact urticaria

Back to list of contact allergens


Referenties
1. Schamberg, I.L., Allergic contact dermatitis to methyl and propyl paraben. Archives of Dermatology, 1967. 95(6): p. 626-8.
2. Fisher, A.A., Paraben dermatitis due to a new medicated bandage: The "paraben paradox". Contact Dermatitis, 1979. 5(4): p. 273-4.
3. Fraki, J.E., L. Peltonen, and V.K. Hopsu-Havu, Allergy to various components of topical preparations in stasis dermatitis and leg ulcer. Contact Dermatitis, 1979. 5(2): p. 97-100.
4. Henry, J.C., E.H. Tschen, and L.E. Becker, Contact urticaria to parabens. Archives of Dermatology, 1979. 115(10): p. 1231-2.
5. Fisher, A.A., Allergen replacement (alternatives) in the management of contact dermatitis. Cutis, 1981. 28(4): p. 368-70, 372.
6. Adams, R.M. and H.I. Maibach, A five-year study of cosmetic reactions. Journal of the American Academy of Dermatology, 1985. 13(6): p. 1062-9.
7. Fisher, A.A., Allergic reactions to contact lens solutions. Cutis, 1985. 36(3): p. 209-11.
8. Menne, T. and N. Hjorth, Routine patch testing with paraben esters. Contact Dermatitis, 1988. 19(3): p. 189-91.
9. Carradori, S., A.M. Peluso, and M. Faccioli, Systemic contact dermatitis due to parabens. Contact Dermatitis, 1990. 22(4): p. 238-9.
10. Seidenari, S., et al., Patch and prick test study of 593 healthy subjects. Contact Dermatitis, 1990. 23(3): p. 162-7.
11. Fisher, A.A., A "current contact news" follow-up: controversial subjects and those resulting in litigation [news]. Cutis, 1993. 52(5): p. 254-6.
12. Perrenoud, D., et al., Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. Contact Dermatitis, 1994. 30(5): p. 276-9.
13. Rastogi, S.C., et al., Contents of methyl-, ethyl-, propyl-, butyl- and benzylparaben in cosmetic products. Contact Dermatitis, 1995. 32(1): p. 28-30.


Author(s):
Allergology: background information on allergens.

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