Hydrocortisone home ICD10: L23.9

Hydrocortisone

Formula CAS
C21H30O5 50-23-7



Background
Hydrocortisone is a low-potency topical and systemic corticosteroid. It has been classified as group A by Coopman et al. According the A-D grouping, patch-test reactions occur 6-7 times more frequently within well-defined groups of structurally related chemicals than between corticosteroids of different groups.

Synonyms
Hydrocortisone
11,17,21-Trihydroxypregn-4-ene-3,20-dione
Cortisol
4-Pregnen-11b,17a,21-triol-3,20-dione
17-Hydroxycorticosterone
Dermacort
Epicort
Hydro-Adresson
Hydrocort
Hydrocortisyl
Hydrocortone
Mildison
Timocort
Proctoscort

Uses
Glucocorticoid
Corticosteroid
Anti-inflammatory
Pharmaceutical

Cross-Reactions
Tixocortol
Prednisolone
Methylprednisolone
Prednisone
Meprednisone

Unusual Reactions

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Referenties
1. Alani, S.D. and M.D. Alani, Allergic contact dermatitis and conjunctivitis to corticosteroids. Contact Dermatitis, 1976. 2(6): p. 301-4.
2. Rietschel, R.L., Photocontact dermatitis to hydrocortisone. Contact Dermatitis, 1978. 4(6): p. 334-7.
3. Dooms-Goossens, A., et al., Contact allergy to hydrocortisone and thixocortol pivalate: problems in the detection of corticosteroid sensitivity. Contact Dermatitis, 1986. 14(2): p. 94-102.
4. Lindelof, B., Contact allergy to hydrocortisone. Contact Dermatitis, 1988. 18(5): p. 309.
5. Coopman, S. and A. Dooms-Goossens, Cross-reactions in topical corticosteroid contact dermatitis. Contact Dermatitis, 1988. 19(2): p. 145-6.
6. Dooms-Goossens, A., Identification of undetected corticosteroid allergy. Contact Dermatitis, 1988. 18(2): p. 124-5.
7. Coopman, S., H. Degreef, and A. Dooms-Goossens, Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. British Journal of Dermatology, 1989. 121(1): p. 27-34.
8. Dooms-Goossens, A.E., et al., Contact allergy to corticosteroids: a frequently missed diagnosis?. Journal of the American Academy of Dermatology, 1989. 21(3 Pt 1): p. 538-43.
9. Lauerma, A.I., Screening for corticosteroid contact sensitivity. Comparison of tixocortol pivalate, hydrocortisone-17-butyrate and hydrocortisone. Contact Dermatitis, 1991. 24(2): p. 123-30.
10. Lauerma, A.I., S. Reitamo, and H.I. Maibach, Systemic hydrocortisone/cortisol induces allergic skin reactions in presensitized subjects. Journal of the American Academy of Dermatology, 1991. 24(2 Pt 1): p. 182-5.
11. Wilkinson, S.M. and J.S. English, Hydrocortisone sensitivity. An investigation into the nature of the allergen. Contact Dermatitis, 1991. 25(3): p. 178-81.
12. Wilkinson, S.M. and J.S. English, Hydrocortisone sensitivity: a prospective study of the value of tixocortol pivalate and hydrocortisone acetate as patch test markers. Contact Dermatitis, 1991. 25(2): p. 132-3.
13. Burden, A.D. and M.H. Beck, Contact hypersensitivity to topical corticosteroids. British Journal of Dermatology, 1992. 127(5): p. 497-500.
14. Schoenmakers, A., et al., Corticosteroid or steroid allergy?. Contact Dermatitis, 1992. 26(3): p. 159-62.
15. Wilkinson, S.M. and J.S. English, Hydrocortisone sensitivity: clinical features of fifty-nine cases. Journal of the American Academy of Dermatology, 1992. 27(5 Pt 1): p. 683-7.
16. Rasanen, L. and T. Hasan, Allergy to systemic and intralesional corticosteroids. British Journal of Dermatology, 1993. 128(4): p. 407-11.
17. Torres, V., et al., Systemic contact dermatitis from hydrocortisone. Contact Dermatitis, 1993. 29(2): p. 106. 18.
18. Wilkinson, S.M., J.S. English, and D.L. Mattey, In vitro evidence of delayed-type hypersensitivity to hydrocortisone. Contact Dermatitis, 1993. 29(5): p. 241-5.
19. Wilkinson, S.M., et al., HLA-A, -B and -DR antigens in hydrocortisone contact hypersensitivity. Contact Dermatitis, 1993. 28(5): p. 295-7.
20. Dooms-Goossens, A., et al., Contact allergy to corticosteroids: the results of a two-centre study. British Journal of Dermatology, 1994. 130(1): p. 42-7.
21. Wilkinson, S.M., et al., Immunohistochemical appearance of corticosteroid contact hypersensitivity reactions. Contact Dermatitis, 1994. 31(5): p. 304-7.
22. Lepoittevin, J.P., J. Drieghe, and A. Dooms-Goossens, Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids [see comments]. Archives of Dermatology, 1995. 131(1): p. 31-7.


Author(s):
Allergology: background information on allergens.

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