Cocamidopropyl betaine home ICD10: L23.9

Cocamidopropyl betaine

Formula CAS
C19H38N2O3 61789-40-0



Background
Cocamidopropyl betaine (CAPB) is an increasingly used surfactant in shampoos, detergents, and cleansing lotions. CAPB is an alkylamidobetaine and functions as an amphoteric surfactant with anionic and cationic properties depending on pH. Betaines are less foaming than other surfactants and are expensive; however, they are relatively gentle to the skin, have a low potential to irritate the eyes, have good conditioning characteristics, and have antibacterial activity. A number of cases of contact allergy to CAPB has been reported in the past several years. In 1200 consecutive patch-test clinic patients, 46 patients (3.8%) had allergic reactions. 3-dimethylaminopropylamine (DMAPA), an aliphatic amine used to synthesize CAPB, has been reported to be the responsible allergen in the CAPB reactions (Angelini et al; Pigatto et al).

Related compound: lauryl hydroxysultaine (SHD), synonyme: Cocoamidopropyl Hydroxy Sulfo Betaine (CHSB), Formula:  RCONH (CH2)3N+(CH3)2CH2CH(OH)CH2SO3- R: Coco, CAS-nr: 86438-79-1.

Synonyms
Tegobetaine L7
N-Cocamidopropyl-N,N-dimethylglycine inner salt
N-(3-Cocoamidopropyl)-betaine
CAPB
Cocoyl amide propyldimethyl glycine
Coconut oil amidopropyl betaine

Uses
Anal detergent
Bath formulations
Contact lens cleaning solutions
Creams
Deodorants
Eye make-up removers
Hair colorants and styling products
Liquid soaps
Shampoos
Shaving products
Toothpastes

Cross-Reactions
Cocobetaine
Triethanolamine
Polyethylene glycol cocamide sulfate
3-dimethylaminopropylamine

Unusual Reactions

Back to list of contact allergens


Referenties
1. Andersen KE, Roed-Petersen J, Kamp P. Contact allergy related to TEA-PEG-3 cocamide sulfate and cocamidopropyl betaine in a shampoo. Contact Dermatitis 1984;11(3):192-193.
2. Cameli N. et al. Eyelid dermatitis due to cocamidopropyl betaine in a hard contact lens solution. Contact Dermatitis 1991;25(4):261-262.
3. Ross JS, White IR. Eyelid dermatitis due to cocamidopropyl betaine in an eye make-up remover. Contact Dermatitis 1991;25(1):64.
4. Korting HC. et al. Allergic contact dermatitis to cocamidopropyl betaine in shampoo. Journal of the American Academy of Dermatology 1992;27(6 Pt 1):1013-1015.
5. Peter C, Hoting E. Contact allergy to cocamidopropyl betaine (CAPB). Contact Dermatitis 1992;26(4):282-283.
6. Taniguchi S. et al. Shampoo dermatitis due to cocamidopropyl betaine. Contact Dermatitis 1992;26(2):139.
7. van der Walle HB, Brunsveld VM. Dermatitis in hairdressers. (I). The experience of the past 4 years. Contact Dermatitis 1994;30(4):217-221.
8. Pigatto P, Bigardi A, Cusano F. Contact dermatitis to cocamidopropylbetaine is caused by residual amines: Relevance, clinical characteristics, and review of the literature. American Journal of Contact Dermatitis 1995;6(1):13-16.


Author(s):
Allergology: background information on allergens.

31-12-2015 (JRM) - www.skin-diseases.eu Terug naar homepagina