| Formula |
CAS |
| C25H32ClFO5 |
25122-46-7 |
Background
Clobetasol-17-propionate is a high-potency topical fluorinated corticosteroid with low systemic effects. It has been classified as group D by Coopman et al. According the A-D grouping, patch-test reactions occur 6-7 times more frequently within well-defined groups of structurally related chemicals than between corticosteroids of different groups.
SynonymsClobetasol-17-propionate
Clobetasol
(11b,16b)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Clobesol
Dermoval
Dermovate
Dermoxin
Dermoxinale
Temovate
UsesAnti-inflammatory
Pharmaceutical
Cross-ReactionsGoup D Corticosteroids
Alclomethasone dipropionate
Betamethasone dipropionate
Betamethasone valerate
Clobetasone-17-butyrate
Clobetasone-17-propionate
Fluocortolone caproate
Fluocortolone pivalate
Fluprenidene acetate
Hydrocortisone-17-butyrate
Hydrocortisone-17-valerate
Unusual ReactionsContact urticaria
Back to list of contact allergens
Referenties
| 1. |
van Ketel WG, Swain AF. Allergy to clobetasol-17-propionate (Dermovate). Contact Dermatitis 1981;7(5):278-279. |
| 2. |
Förström L, Lassus A, Salde L, Niemi KM. Allergic contact eczema from topical corticosteroids. Contact Dermatitis 1982;8(2):128-133. |
| 3. |
Chalmers RJ, Beck MH, Muston HL. Simultaneous hypersensitivity to clobetasone butyrate and clobetasol propionate. Contact Dermatitis 1983;9(4):317-318. |
| 4. |
Boyle J, Peachey RD. Allergic contact dermatitis to Dermovate and Eumovate. Contact Dermatitis 1984;11(1):50-51. |
| 5. |
Tosti A, Guerra L, Manuzzi P, Lama L. Contact dermatitis from clobetasol propionate. Contact Dermatitis 1987;17(4):256-257. |
| |
Cox NH. Contact allergy to clobetasol propionate. Arch Dermatol 1988;124(6):911-913. |
| 6. |
Coopman S, Degreef H, Dooms-Goossens A. Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. Br J Dermatol 1989;121(1):27-34. |
| 7. |
Lepoittevin JP, Drieghe J, Dooms-Goossens A. Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids. Arch Dermatol 1995;131(1):31-37. |
Author(s):Allergology: background information on allergens.
ICD10: L23.9