Cinnamic aldehyde home ICD10: L23.9

Cinnamic aldehyde

Formula CAS
C9H8O 104-55-2



Background
Cinnamic aldehyde is a naturally occuring fragrance with the strong odor of cinnamon. It is found in cinnamon leaves, cinnamon bark, and the essential oils of hyacinth, myrrh, Bulgarian rose, patchouli, and other plants. Cinnamic aldehyde is used as a fragrance in cosmetics and over-the-counter drugs as well as a flavoring agent in beverages, chewing gum, mouthwashes, and toothpaste. Oral symptoms from toothpaste containing cinnamic aldehyde include sore mouth, dermatitis of the lips and perioral skin, swelling of the tongue, and mouth ulceration. The International Fragrance Association recommends that cinnamic aldehyde be used with an equal proportion by weight of eugenol or d-limonene to prevent sensitization. This process is known as quenching.

Synonyms
2-Propenal-3-phenyl
3-Phenyl-2-propenal
Cinnamal (CTFA adopted name)
Cinnamaldehyde
Cinnamic aldehyde
Phenylacrolein

Uses
Balsam of Tolu and Balsam of Peru
Cinnamon, Ceylon, and Cassia oil
Foods (cola, chocolate, ice cream, chewing gums)
Fragranced household products such as deodorizers, detergents, and soaps
Perfumes
Plants (hyacinth, etc.)
Spices
Toothpaste

Cross-Reactions
Cinnamic acid
Cinnamic alcohol
Cinnamon oil

Unusual Reactions
Depigmentation
Non immunologic Contact urticaria
Photoallergy

Back to list of contact allergens


Referenties
1. Mathias CG, Chappler RR, Maibach HI. Contact urticaria from cinnamic aldehyde. Arch Dermatol 1980;116(1):74-76.
2. Guin JD, Meyer BN, Drake RD, Haffley P. The effect of quenching agents on contact urticaria caused by cinnamic aldehyde. J Am Acad Dermatol 1984;10(1):45-51.
3. Maibach HI. Cheilitis: occult allergy to cinnamic aldehyde. Contact Dermatitis 1986;15(2):106-107.
4. Speight EL, Lawrence CM. Cinnamic aldehyde 2% pet. is irritant on patch testing. Contact Dermatitis, 1990;23(5):379-380.
5. Malten KE, van Ketel WG, Nater JP, Liem DH. Reactions in selected patients to 22 fragrance materials. Contact Dermatitis 1984;11(1):1-10.
6. Meding B. Skin symptoms among workers in a spice factory. Contact Dermatitis 1993;29(4):202-205.
7. Seite-Bellezza D, el Sayed F, Bazex J. Contact urticaria from cinnamic aldehyde and benzaldehyde in a confectioner. Contact Dermatitis 1994;31(4):272-273.
8. Manzur F, el Sayed F, Bazex J. Contact allergy to cinnamic aldehyde and cinnamic alcohol in Oléophytal. Contact Dermatitis 1995;32(1):55.


Author(s):
Allergology: background information on allergens.

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