| Formula |
CAS |
| C6H4(NH2)2 . 2HCl |
615-28-1 |
Background4-Phenylenediamine dihydrochloride is
a primary intermediate in permanent hair dyes and fur dyes.
Synonyms
1,4-Benzenediamine
1,4-Phenylenediamine
4-Phenylenediamine
p-Diaminobenzene
Orsin
C.I. 76076
p-Amimoaniline
p-Diaminobenzene
Rodol D
Ursol
D
UsesCosmetics (permanent hair colors, some dark-colored
cosmetics)
Lithography (printing inks)
Oils, greases, gasoline
Photocopying
Photographic developers
Primary intermediate in the production of azo dyes
Rarely, fur and leather dyes
Rubber and plastic industry (antioxidants and
accelerators)
Cross-ReactionsParabens
PABA
Para group of compounds
Unusual ReactionsAirborne
contact dermatitis
Contact urticaria
Erythema multiforme-like reactions
Photoallergy
Back to list of contact
allergens
Referenties
| 1. |
Adams RM, Maibach HI. A five-year study of
cosmetic reactions. J Am Acad Dermatol 1985 Dec;13(6):1062-1069. |
| 2. |
Edwards EK Jr, Edwards EK. Contact urticaria
and allergic contact dermatitis caused by paraphenylenediamine.
Cutis 1984 Jul;34(1):87-88. |
| 3. |
Foussereau J, Reuter G, Petitjean J. Is hair
dyed with PPD-like dyes allergenic? Contact Dermatitis 1980 Jan;6(2):143. |
| 4. |
Maibach HI. Paraphenylenediamine-free hair
coloring mousse. Contact Dermatitis 1986 Aug;15(2):103. |
| 5. |
Nethercott JR, MacPherson M, Choi BC, Nixon
P. Contact dermatitis in hairdressers. Contact Dermatitis 1986 Feb;14(2):73-79. |
| 6. |
Picardo M, Zompetta C, Marchese C, De Luca
C, Faggioni A, Schmidt RJ, Santucci B. Paraphenylenediamine, a contact
allergen, induces oxidative stress and ICAM-1 expression in human
keratinocytes. Br J Dermatol 1992 May;126(5):450-455. |
| 7. |
Shimunes E. Purpuric allergic contact dermatitis
to paraphenylenediamine. Contact Dermatitis 1978 Aug;4(4):225-229. |
| 8. |
Sutthipisal N, McFadden JP, Cronin E. Sensitization
in atopic and non-atopic hairdressers with hand eczema. Contact
Dermatitis 1993 Oct;29(4):206-269. |
| 9. |
Temesvari E. Contact urticaria from paraphenylenediamine.
Contact Dermatitis 1984 Aug;11(2):125. |
| 10. |
Storrs FJ. et al. Paraphenylenediamine dihydrochloride.
Contact Dermatitis 1979;5(2):126. |
Author(s):Allergology: background information on allergens.
ICD10: L23.9