2-Bromo-2-nitropropane-1,3-diol (Bronopol) home codes: L23.9

2-Bromo-2-nitropropane-1,3-diol (Bronopol)

Formula CAS
C3H6BrNO4 52-51-7



Background
Bronopol is a broad-spectrum preservative and antiseptic used in cosmetics, topical medicaments, and industry. Cosmetic preparations contain bronopol in concentrations of 0.01% to 0.02%. When the concentration is raised to 1% or greater, it may be a significant irritant. Bronopol is a formaldehyde-releasing preservative and concomitant sensitization to bronopol and formaldehyde occurs in about a third of patch test clinic patients.

Synonyms
1,3-Propanediol-2-Bromo-2-Nitro
2-Bromo-2-nitro-1,3-propanediol
2-Bromo-2-Nitropropane-1,3-Diol
b-Bromo-b-nitrotrimethyleneglycol
Bronopol
Bronosol
Lexgard bronopol
Onyxide 500

Uses
Cooling fluids
Cosmetics
Creams and lotions
Detergents
Hair dressing
Humidifers
Mascaras
Milk sampling
Paints
Shampoos
Textiles
Topical medications

Cross-Reactions
Formaldehyde

Unusual Reactions
Contact urticaria

Back to list of contact allergens


Referenties
1. Camarasa JG. Contact dermatitis due to Bronopol. Contact Dermatitis 1986;14(3):191-192.
2. Ford GP, Beck MH. Reactions to Quaternium 15, Bronopol and Germall 115 in a standard series. Contact Dermatitis 1986;14(5):271-274.
3. Frosch PJ, White IR, Rycroft RJ, Lahti A, Burrows D, Camarasa JG, Ducombs G, Wilkinson JD. Contact allergy to Bronopol. Contact Dermatitis 1990;22(1):24-26.
4. Perrenoud D, Bircher A, Hunziker T, Suter H, Bruckner-Tuderman L, Stäger J, Thürlimann W, Schmid P, Suard A, Hunziker N. Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. Contact Dermatitis 1994;30(5):276-279.


Author(s):
Allergology: background information on allergens.

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